abstract：:The localization of CGRP mRNA in neurons of the rat brain and spinal cord was assessed by in situ hybridization histochemistry (ISH) using a radiolabeled synthetic 57-mer oligodeoxynucleotide probe complementary to the rat prepro CGRP mRNA. Results were compared with previously published findings of CGRP-immunoreactiv...

journal_title：Brain research bulletin

authors： Kresse A,Jacobowitz DM,Skofitsch G

更新日期：1995-01-01 00:00:00

abstract：:The subiculum may be the key structure in the transfer of relevant processed information from the hippocampal formation to cortical areas. We investigated the location of the serotonin 1B receptor (5-HT1B) in the hippocampus with the specific ligand serotonin-O-carboxymethyl-glycyl[125I]tyrosinamide in rat brain secti...

journal_title：Brain research bulletin

authors： Aït Amara D,Segu L,Naïli S,Buhot MC

更新日期：1995-01-01 00:00:00

abstract：:The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/lgb, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/lbg (HS) and the lon...

journal_title：Brain research bulletin

authors： Yanai J,Pick CG

更新日期：1995-01-01 00:00:00

abstract：:A preembedding double immunostaining technique using antibodies against methionine-enkephalin and tyrosine hydroxylase was used to study synaptic relations between enkephalinergic and catecholaminergic neurons in the area postrema of the rat at the electron microscopic level. The large nuclei-containing cell bodies of...

journal_title：Brain research bulletin

authors： Guan JL,Wang QP,Shioda S,Ochiai H,Nakai Y

更新日期：1995-01-01 00:00:00

abstract：:The effects of a unilateral lesion made on the right or left side of the preoptic area (POA) or anterior hypothalamic area (AHA) made on each day of the estrous cycle, were analyzed. Ovulation rate decreased among the animals with a lesion performed on the day of estrous on the right side of POA (1/7 vs. 7/7, p < 0.05...

journal_title：Brain research bulletin

authors： Morán JL,Cruz ME,Dominquez R

更新日期：1994-01-01 00:00:00

abstract：:The effects of unilateral and bilateral electrolytic lesions of the dorsal raphe nuclei (DRN) of 30-day-old rats, on the spontaneous and induced ovulation, were analyzed. The bilateral lesion and the lesion on the right side of the DRN delayed the age of first vaginal estrous. None of the animals with bilateral lesion...

journal_title：Brain research bulletin

authors： Ayala ME,Rosas P,Dominguez R

更新日期：1994-01-01 00:00:00

abstract：:In the preceding article, a dorsochiasmatic area (DCh) was described that projects to both paraventricular (PVN) and supraoptic (SON) nuclei. The main afferents of the DCh, revealed by local injections of retrograde tracers, are the hypothalamic PVN and SON, lateral septal nuclei (LSV and SHy), bed nuclei of the stria...

journal_title：Brain research bulletin

authors： Thellier D,Moos F,Richard P,Stoeckel ME

更新日期：1994-01-01 00:00:00

abstract：:This study tested for the presence of androgen receptor-immunoreactivity in somatostatin, galanin, vasopressin, corticotropin-releasing hormone, and oxytocin neurons in the rat forebrain. The brains of adult male Sprague-Dawley rats were fixed with 4% paraformaldehyde. Androgen receptor was visualized in coronal secti...

journal_title：Brain research bulletin

authors： Bingaman EW,Baeckman LM,Yracheta JM,Handa RJ,Gray TS

更新日期：1994-01-01 00:00:00

abstract：:Serotonin has been postulated to influence several developmental parameters. The potential role of serotonin in the development of the rat olfactory bulb, a simple cortical structure, was determined following selective depletion of serotonin to the olfactory bulb of neonate rats. In the neonate, 5,7-dHT was injected i...

journal_title：Brain research bulletin

authors： McLean JH,Darby-King A

更新日期：1994-01-01 00:00:00

abstract：:Opioid antagonists such as naltrexone, naloxone, and ICI174864 induce a transient downregulation of delta opioid receptors prior to upregulation in NG108-15 cells. Here we show that naltrexone can also elicit a transient downregulation of delta 2 opioid receptors preceding upregulation in brain. A 1 h treatment of rat...

journal_title：Brain research bulletin

authors： Belcheva MM,Barg J,Mchale R,Coscia CJ

更新日期：1994-01-01 00:00:00

abstract：:The effect of lithium chloride on the activity of the afferent nerve fibers from the abdominal organs was studied in anesthetized rats. The administration of the lithium chloride solution (0.15 M) over the mesentery increased afferent discharge rate of the splanchnic and vagal gastric nerve. Injection of the same solu...

journal_title：Brain research bulletin

authors： Niijima A,Yamamoto T

更新日期：1994-01-01 00:00:00

abstract：:The present study was conducted to examine the effects of d-amphetamine and the designer drugs 3,4-methylenedioxymethamphetamine (MDMA), N-methyl-3,4-methylenedioxyphenyl-3-butamine (HMDMA), 3,4-methylenedioxyphenyl-2-butanamine (BDB), 3,4-methylenedioxyphenyl-1-ethanamine (MDM1EA) in the chick embryo and the young ch...

journal_title：Brain research bulletin

authors： Bronson ME,Jiang W,Clark CR,DeRuiter J

更新日期：1994-01-01 00:00:00

abstract：:Rats received bilateral intracerebroventricular (ICV) infusions of either AF64A (1.5 nmol/ventricle; n = 9) or vehicle (3.0 microliters/ventricle; n = 7). Four weeks later, the animals were anesthetized and their brains processed to visualize and quantify choline acetyltransferase (ChAT) immunoreactive (IR) and parval...

journal_title：Brain research bulletin

authors： Dong XW,Hanin I,Lorens SA

更新日期：1994-01-01 00:00:00

abstract：:A new silver method for senile plaques and neurofibrillary tangles (NFT) in paraffin sections is presented. This new technique is rapid in execution (15 min) and reveals senile plaques of all morphological types as well as NFT. The silver staining is spatially congruent with immunocytochemical staining for the beta-am...

journal_title：Brain research bulletin

authors： Hedreen JC,Raskin LS,Price DL

更新日期：1994-01-01 00:00:00

abstract：:In precollicular decerebrate cats, the vestibulospinal reflex (VSR) was intermittently recorded from the triceps brachii during sinusoidal roll tilt of the whole animal (at 0.15 Hz, +/- 10 degrees), leading to selective stimulation of labyrinth receptors. This reflex, tested during and after a 3-h period of sustained ...

journal_title：Brain research bulletin

authors： Pompeiano O,Manzoni D,D'Ascanio P,Andre P

更新日期：1994-01-01 00:00:00

abstract：:We have studied the molecular and cellular mechanisms underlying the acute and chronic effects of opiate on neurons of the rat locus coeruleus (LC). Acutely, opiates inhibit LC neurons by activating K+ channels and inhibiting a novel sodium-dependent inward current. Both of these actions are mediated via pertussis tox...

journal_title：Brain research bulletin

authors： Nestler EJ,Alreja M,Aghajanian GK

更新日期：1994-01-01 00:00:00

abstract：:Male and female rats were treated daily for 7 days with mazindol (5, 10, and 20 mg/kg), an anorectic drug, and tested in the open field. Mazindol developed sensitization to its locomotor stimulatory effect in both sexes on day 7 with a nondose-dependent pattern of response. However, the locomotor activity appeared to ...

journal_title：Brain research bulletin

authors： Zanin M,Takahashi RN

更新日期：1994-01-01 00:00:00

abstract：:The microdialysis method was utilized to study the effects of N omega-nitro-L-arginine (L-NNA) and N omega-nitro-D-arginine (D-NNA), an inhibitor of nitric oxide (NO) synthesis from L-arginine and its D-enantiomer, on spontaneous and N-methyl-D-aspartate (NMDA)-evoked overflow of striatal extracellular dopamine (DA) i...

journal_title：Brain research bulletin

authors： Ishida Y,Yamamoto R,Mitsuyama Y

更新日期：1994-01-01 00:00:00

abstract：:Postmortem caudate and substantia nigra tissue samples from human parkinsonian patients (PD) and age-matched controls (NC) were analyzed for uric acid (UA), dopamine (DA), and ascorbic acid (AA) by HPLC/UV/ED. Uric acid and DA levels were significantly lower in the substantia nigra of PD by 54% and 85%, respectively. ...

journal_title：Brain research bulletin

authors： Church WH,Ward VL

更新日期：1994-01-01 00:00:00

abstract：:Both the lateral hypothalamus (LH) and reticular thalamus (RT) have been implicated in the integration of a variety of vital functions. To determine relevant connections more specifically between cells of these two regions in the rat, functional neurophysiological and horseradish peroxidase (HRP) histochemical techniq...

journal_title：Brain research bulletin

authors： Barone FC,Cheng JT,Wayner MJ

更新日期：1994-01-01 00:00:00

abstract：:Massively obese males often show symptoms of hypogonadism, but the mechanism for this is unclear. Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism. If this hypothesis is correct, ...

journal_title：Brain research bulletin

authors： Blank DM,Clark RV,Heymsfield SB,Rudman DR,Blank MS

更新日期：1994-01-01 00:00:00

abstract：:Electrophysiologic response characteristics of mouse sciatic nerve and spinal cord were investigated following CNS infection with the temperature-sensitive (ts) vesicular stomatitis virus (VSV) mutant G31 KS5. Measurements were obtained before clinical symptoms of the virus-induced CNS disease appeared. Sciatic nerve ...

journal_title：Brain research bulletin

authors： Gerren RA,Johnson TC

更新日期：1994-01-01 00:00:00

abstract：:In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and ...

journal_title：Brain research bulletin

authors： Colombari DS,Haibara AS,Camargo LA,Saad WA,Renzi A,DeLuca LA Jr,Menani JV

更新日期：1994-01-01 00:00:00

abstract：:4-Hydroxy-4-phenylcaproamide (HPhCA), at high doses or rates of IV injection depressed the ventral root reflexes elicited by nerve or dorsal root stimulation. The D (direct) and I (synaptic) ventral root waves and the antidromic (A) dorsal root wave evoked by intraspinal stimulation were also depressed. Similar effect...

journal_title：Brain research bulletin

authors： Dueñas SH,Muñoz-Martínez EJ,Joseph-Nathan P

更新日期：1994-01-01 00:00:00

abstract：:Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH...

journal_title：Brain research bulletin

authors： Damaj MI,Glennon RA,Martin BR

更新日期：1994-01-01 00:00:00

abstract：:Tetramethylrhodamine-dextran is a highly fluorescent neuroanatomical tracer that, in its 10,000 MW form, has seen widespread use as a sensitive anterograde tract-tracing label. We report here the use of a lower molecular weight tetramethylrhodamine-dextran (3000 MW; Molecular Probes, OR) as an in vivo intracellular ma...

journal_title：Brain research bulletin

authors： Carr PA,Noga BR,Nance DM,Jordan LM

更新日期：1994-01-01 00:00:00

abstract：:The mechanism of action of the anticonvulsant drug valproic acid (VPA) was studied in rat amygdaloid slices using intracellular recording techniques. In the presence of bicuculline (20 microM), stimulation of the endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP) followed by a paroxysmal depolariz...

journal_title：Brain research bulletin

authors： Gean PW,Huang CC,Hung CR,Tsai JJ

更新日期：1994-01-01 00:00:00

abstract：:Comparison of detailed physiological and morphological data shows that the hypothalamic aggression region in the rat largely coincides with the intermediate hypothalamic area. This region has a neuronal density of about 35.10(3) neurons per mm3, a synaptic density of about 300.10(6) per mm3, and a synapse to neuron ra...

journal_title：Brain research bulletin

authors： Aalders TT,Meek J

更新日期：1993-01-01 00:00:00

abstract：:A high correlation between alcohol use and smoking has long been suggested by epidemiological data. We examined the potential behavioral interactions between ethanol and nicotine using ethanol-induced motor incoordination as the test response in mice. Effect of pretreatment of various doses of (-)-nicotine, (-)-cotini...

journal_title：Brain research bulletin

authors： Dar MS,Li C,Bowman ER

更新日期：1993-01-01 00:00:00

abstract：:We have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion to the substantia nigra (SN) and the locus coeruleus (LC) both produce a long-lasting neurotoxicity on dopamine (DA) and norepinephrine (NE) neurons in these two areas, respectively. In the present study, we furth...

journal_title：Brain research bulletin

authors： Chang FW,Wang SD,Lu KT,Lee EH

更新日期：1993-01-01 00:00:00

abstract：:The effects of intracarotidly injected neuropeptide Y (NPY; 0.1 micrograms/kg) on the local cerebral blood volume (CBV) and blood flow (CBF) in the parieto-temporal cortex were examined by the photoelectric method in 17 anesthetized cats. CBV reflects the cumulative crosssectional area of the cerebral microvascular be...

journal_title：Brain research bulletin

authors： Kobari M,Fukuuchi Y,Tomita M,Tanahashi N,Yamawaki T,Takeda H,Matsuoka S

更新日期：1993-01-01 00:00:00

abstract：:Development and resolution of the lesion produced by occlusion of the middle cerebral artery (MCAO) was studied through quantitative planimetry and histologic/immunohistochemical techniques. MCAO, performed in spontaneously hypertensive rats (SHR), initially (1-3 days) produced large, consistent cerebral cortical infa...

journal_title：Brain research bulletin

authors： Clark RK,Lee EV,Fish CJ,White RF,Price WJ,Jonak ZL,Feuerstein GZ,Barone FC

更新日期：1993-01-01 00:00:00

abstract：:The effects of streptozotocin-induced (STZ) diabetes on the release of gonadotropins was studied in female rats. In the first experiment, rats were ovariectomized and 2 days later were injected with STZ. Three weeks later rats were treated with estrogen and progesterone and blood samples were taken via intraatrial can...

journal_title：Brain research bulletin

authors： Kienast SG,Fadden C,Steger RW

更新日期：1993-01-01 00:00:00

abstract：:Spontaneous locomotion and motor coordination was evaluated in young (5-6 month old) and aged (24-25 month old) rats. Animals were tested for spontaneous locomotor activity in Digiscan Animal Activity Monitors during the nocturnal cycle. Aged animals exhibited a significant hypoactivity compared to their young counter...

journal_title：Brain research bulletin

authors： Emerich DF,McDermott P,Krueger P,Banks M,Zhao J,Marszalkowski J,Frydel B,Winn SR,Sanberg PR

更新日期：1993-01-01 00:00:00

abstract：:Under standard laboratory conditions rats given access to three separate macronutrient sources compose a diet yielding 31% of their total daily calories as protein, 34% as carbohydrate, and 34% as fat. This selection pattern is dramatically altered with restored access following a 48 h fast. During the first hour of r...

journal_title：Brain research bulletin

authors： Bernardini J,Kamara K,Castonguay TW

更新日期：1993-01-01 00:00:00

abstract：:Mice selected for differences in nest-building behavior differ in the number of arginine-vasopressin (AVP)-immunoreactive neurons in the suprachiasmatic nuclei (SCN). Although previous efforts to link AVP-immunoreactive neurons in the SCN to clock function have failed, we show that differences in several circadian par...

journal_title：Brain research bulletin

authors： Bult A,Hiestand L,Van der Zee EA,Lynch CB

更新日期：1993-01-01 00:00:00

abstract：:The labelling of hypothalamic binding sites by [125I]-FK, a specific mu-opioid receptor ligand, was studied in female C57BL/6J mice to test whether removal of ovarian steroids affected the density of distribution of receptor binding. Labelling densities in the forebrain of normally cycling (intact) females (N = 12), w...

journal_title：Brain research bulletin

authors： Joshi D,Billiar RB,Miller MM

更新日期：1993-01-01 00:00:00

abstract：:The expression of dopamine by primary sensory neurons and their peripheral projections was studied in the chick dorsal root ganglion by means of immunocytochemical procedures. Within the sensory neurons, dopamine immunoreactivity is first expressed by 0.8% of cells at E10 and reaches a percentage of 5.6% before hatchi...

journal_title：Brain research bulletin

authors： Philippe E,Zhou C,Audet G,Geffard M,Gaulin F

更新日期：1993-01-01 00:00:00

abstract：:Several studies have demonstrated that a descending dopaminergic pathway innervates the dorsal and the intermediate gray matter of the spinal cord and have suggested that this pathway is involved in pain modulation and in the control of autonomic functions. Other studies have also demonstrated the presence of dopamine...

journal_title：Brain research bulletin

authors： Weil-Fugazza J,Godefroy F

更新日期：1993-01-01 00:00:00

abstract：:In previous studies we have demonstrated that spinal motoneurons in the adult cat can regenerate CNS-type axons through CNS scar tissue into denervated ventral roots. This scar tissue, which appears to support and sustain the growth of injured CNS axons, has been shown to have a persistent defect in the blood-brain ba...

journal_title：Brain research bulletin

authors： Risling M,Fried K,Linda H,Carlstedt T,Cullheim S

更新日期：1993-01-01 00:00:00